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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP14
All Species:
26.06
Human Site:
S260
Identified Species:
38.22
UniProt:
P54578
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54578
NP_001032411.1
494
56069
S260
T
T
M
K
C
T
E
S
E
E
E
E
V
T
K
Chimpanzee
Pan troglodytes
P60051
493
55922
S260
T
T
M
K
C
T
E
S
E
E
E
E
V
T
K
Rhesus Macaque
Macaca mulatta
XP_001090667
458
52239
K232
S
E
E
E
E
V
T
K
G
K
E
N
Q
L
Q
Dog
Lupus familis
XP_537306
545
61461
S311
T
T
M
K
C
T
E
S
E
E
E
E
V
T
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9JMA1
493
55983
S260
T
T
M
K
C
T
E
S
E
E
E
E
V
T
K
Rat
Rattus norvegicus
NP_001008302
493
55958
S260
T
T
M
K
C
T
E
S
E
E
E
E
V
T
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519267
431
48760
G205
E
E
E
E
A
T
K
G
K
E
N
Q
L
Q
L
Chicken
Gallus gallus
XP_419150
492
55612
A258
T
V
M
K
C
T
E
A
E
E
E
E
V
T
K
Frog
Xenopus laevis
Q6GNI6
523
60030
Y256
H
A
R
H
L
A
G
Y
E
Q
Q
D
A
H
E
Zebra Danio
Brachydanio rerio
A6H8I0
506
58102
N264
H
R
H
C
K
D
D
N
G
K
K
A
N
N
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609377
475
53689
D247
V
K
M
S
S
E
E
D
P
D
E
P
S
T
V
Honey Bee
Apis mellifera
XP_395043
497
56311
S255
T
E
L
K
C
I
E
S
E
D
E
P
P
T
K
Nematode Worm
Caenorhab. elegans
Q17361
489
55859
K237
E
S
D
E
V
S
E
K
K
V
E
R
N
N
Q
Sea Urchin
Strong. purpuratus
XP_786966
516
58357
S261
S
M
L
K
C
I
E
S
E
E
E
P
P
V
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q949Y0
482
53677
Q240
L
Q
S
R
L
H
C
Q
E
S
G
E
E
S
S
Baker's Yeast
Sacchar. cerevisiae
P43593
499
57092
N246
T
T
I
K
D
T
A
N
D
N
D
I
T
V
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
92.5
89.9
N.A.
96.7
96.5
N.A.
80.3
90.4
21.4
20.1
N.A.
54.6
61.7
41.9
61
Protein Similarity:
100
99.8
92.7
90.2
N.A.
98.5
98.7
N.A.
83.8
94.9
39
38.7
N.A.
71.2
80.2
61.1
76.5
P-Site Identity:
100
100
6.6
100
N.A.
100
100
N.A.
13.3
86.6
6.6
0
N.A.
26.6
60
13.3
53.3
P-Site Similarity:
100
100
33.3
100
N.A.
100
100
N.A.
46.6
93.3
33.3
26.6
N.A.
33.3
73.3
46.6
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.5
26
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.9
46.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
7
7
7
7
0
0
0
7
7
0
0
% A
% Cys:
0
0
0
7
50
0
7
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
0
7
7
7
7
7
13
7
7
0
0
0
% D
% Glu:
13
19
13
19
7
7
63
0
63
50
69
44
7
0
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
7
7
13
0
7
0
0
0
0
% G
% His:
13
0
7
7
0
7
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
0
7
0
0
13
0
0
0
0
0
7
0
0
0
% I
% Lys:
0
7
0
57
7
0
7
13
13
13
7
0
0
0
57
% K
% Leu:
7
0
13
0
13
0
0
0
0
0
0
0
7
7
7
% L
% Met:
0
7
44
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
13
0
7
7
7
13
13
0
% N
% Pro:
0
0
0
0
0
0
0
0
7
0
0
19
13
0
7
% P
% Gln:
0
7
0
0
0
0
0
7
0
7
7
7
7
7
13
% Q
% Arg:
0
7
7
7
0
0
0
0
0
0
0
7
0
0
0
% R
% Ser:
13
7
7
7
7
7
0
44
0
7
0
0
7
7
7
% S
% Thr:
50
38
0
0
0
50
7
0
0
0
0
0
7
50
0
% T
% Val:
7
7
0
0
7
7
0
0
0
7
0
0
38
13
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _